Article Navigation
- < Previous
- Next >
Journal Article
Get access
Jing Cao , Jing Cao University of Minnesota , Minneapolis, MN 55455 Search for other works by this author on: Oxford Academic Kerry A Schwichtenberg University of Minnesota , Minneapolis, MN 55455 Search for other works by this author on: Oxford Academic Naomi Q Hanson University of Minnesota , Minneapolis, MN 55455 Search for other works by this author on: Oxford Academic Michael Y Tsai University of Minnesota , Minneapolis, MN 55455 Address correspondence to this author at: 420 Delaware St. SE, Mayo Mail Code 609, Minneapolis, MN 55455-0392. Fax 612-625-1121; e-mail [emailprotected]. Search for other works by this author on: Oxford Academic
Clinical Chemistry, Volume 52, Issue 12, 1 December 2006, Pages 2265–2272, https://doi.org/10.1373/clinchem.2006.072322
Published:
01 December 2006
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
Jing Cao, Kerry A Schwichtenberg, Naomi Q Hanson, Michael Y Tsai, Incorporation and Clearance of Omega-3 Fatty Acids in Erythrocyte Membranes and Plasma Phospholipids, Clinical Chemistry, Volume 52, Issue 12, 1 December 2006, Pages 2265–2272, https://doi.org/10.1373/clinchem.2006.072322
Close
Search
Close
Search
Advanced Search
Search Menu
AI Discovery Assistant
Abstract
Background: The sum of eicosapentaenoic acid (EPA, 20:5 ω3) and docosahexaenoic acid (DHA, 22:6 ω3) in erythrocyte membranes, termed the omega-3 index, can indicate suboptimal intake of omega-3 fatty acids, a risk factor for cardiovascular disease (CVD). To study the effects of fatty acid supplementation, we investigated the rate of incorporation and clearance of these fatty acids in erythrocyte membranes and plasma after intake of supplements.
Methods: Twenty study participants received supplementation with either fish oil (1296 mg EPA + 864 mg DHA/day) or flaxseed oil (3510 mg alpha-linolenic acid + 900 mg linoleic acid/day) for 8 weeks. We obtained erythrocyte membrane and plasma samples at weeks 0, 4, 8, 10, 12, 14, 16, and 24 and extracted and analyzed fatty acids by gas chromatography.
Results: After 8 weeks of fish oil supplementation, erythrocyte membrane EPA and DHA increased 300% (P <0.001) and 42% (P <0.001), respectively. The mean erythrocyte omega-3 index reached a near optimal value of 7.8%, and remained relatively high until week 12. EPA and DHA showed greater increases and more rapid washout period decreases in plasma phospholipids than in erythrocyte membranes. Flaxseed oil supplementation increased erythrocyte membrane EPA to 133% (P <0.05) and docosapentaenoic acid (DPA, 22:5 ω3) to 120% (P <0.01) of baseline, but DHA was unchanged. In plasma phospholipids, EPA, DPA, and DHA showed a slight but statistically insignificant increase.
Conclusions: Erythrocyte membrane EPA+DHA increases during relatively short intervals in response to supplementation at rates related to amount of supplementation. These results may be useful to establish appropriate dosage for omega-3 fatty acid supplementation.
© 2006 The American Association for Clinical Chemistry
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Issue Section:
Articles > Lipids, Lipoproteins, and Cardiovascular Risk Factors
You do not currently have access to this article.
Download all slides
Sign in
Get help with access
-
ADLM members
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Incorporation and Clearance of Omega-3 Fatty Acids in Erythrocyte Membranes and Plasma Phospholipids - 24 Hours access
EUR €39.00
GBP £33.00
USD $43.00
Rental
This article is also available for rental through DeepDyve.
Advertisement
Citations
Views
2,585
Altmetric
More metrics information
Metrics
Total Views 2,585
1,813 Pageviews
772 PDF Downloads
Since 1/1/2020
| Month: | Total Views: |
|---|---|
| January 2020 | 11 |
| February 2020 | 29 |
| March 2020 | 12 |
| April 2020 | 13 |
| May 2020 | 8 |
| June 2020 | 5 |
| July 2020 | 34 |
| August 2020 | 50 |
| September 2020 | 48 |
| October 2020 | 42 |
| November 2020 | 51 |
| December 2020 | 24 |
| January 2021 | 55 |
| February 2021 | 38 |
| March 2021 | 46 |
| April 2021 | 60 |
| May 2021 | 47 |
| June 2021 | 36 |
| July 2021 | 42 |
| August 2021 | 43 |
| September 2021 | 50 |
| October 2021 | 40 |
| November 2021 | 49 |
| December 2021 | 47 |
| January 2022 | 36 |
| February 2022 | 32 |
| March 2022 | 44 |
| April 2022 | 35 |
| May 2022 | 27 |
| June 2022 | 54 |
| July 2022 | 47 |
| August 2022 | 58 |
| September 2022 | 45 |
| October 2022 | 35 |
| November 2022 | 45 |
| December 2022 | 37 |
| January 2023 | 80 |
| February 2023 | 63 |
| March 2023 | 75 |
| April 2023 | 34 |
| May 2023 | 47 |
| June 2023 | 31 |
| July 2023 | 49 |
| August 2023 | 35 |
| September 2023 | 47 |
| October 2023 | 35 |
| November 2023 | 26 |
| December 2023 | 51 |
| January 2024 | 60 |
| February 2024 | 49 |
| March 2024 | 55 |
| April 2024 | 67 |
| May 2024 | 47 |
| June 2024 | 91 |
| July 2024 | 28 |
| August 2024 | 52 |
| September 2024 | 38 |
| October 2024 | 65 |
| November 2024 | 18 |
| December 2024 | 7 |
| January 2025 | 10 |
| February 2025 | 17 |
| March 2025 | 11 |
| April 2025 | 8 |
| May 2025 | 14 |
Altmetrics
× Close Modal
Email alerts
New journal issues
New journal articles
Sign up for marketing
New journal issues alert
To set up an email alert, please sign in to your personal account, or register
Sign in
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Journal article activity alert
To set up an email alert, please sign in to your personal account, or register
Sign in
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Citing articles via
Google Scholar
-
Latest
-
Most Read
-
Most Cited
More from Oxford Academic
Biochemistry
Biological Sciences
Medical Skills
Medicine and Health
Pathology
Research Methods in Life Sciences
Science and Mathematics
Books
Journals
Advertisement
